This card is probably most at home with commanders such as Urza, High Lord Artificer and Teferi, Temporal Archmage that can run a good number of basic lands and have built-in ways to break parity on the effect through untapping and mana production
If you do, tap that creature and it gains indestructible until end of turn
For example, for RNA, I had 28 of the 60 (4x15) total Mythics
Sure, you have to build your deck somewhat around being able to usefully play Upheaval but given that it is such a good counter to so many of the things going on in the cube, one of the very best safety buttons in the game, that it remains one of the most feared cards in cube
A master of light and shadow with that Aethershield Artificer twinkle in the eye, those Goblin Researchers hands, and the bad ass attitude of Dovin's Veto and Fairgrounds Warden, his characters all have this feeling of being caught in the middle of something awesome, but pausing, for a sec, looking at you through the frame of the card and asking you to check out whats next
Eaten Alive With the right supporting cast (i.e., Infestation Sage, Burglar Rat), Eaten Alive is disgustingly efficient removal